Understanding how skin immune cells regulate inflammation and metabolism
Official title: Metabolic and epigenetic regulation of skin Tregs
Funded at Emory University · NIH-11104958 · Data updated 2026-11-12
This study is looking at special immune cells in the skin that help keep inflammation in check and keep your skin healthy, and it aims to understand how these cells adapt to their surroundings, which could help find new ways to treat skin-related immune issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $597,542 |
| NIH project number | 1R01AI190202-01 |
| Project ID | NIH-11104958 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from skin inflammatory conditions, particularly those with allergic dermatitis or eczema.
✕Less likely to help
Patients with non-inflammatory skin conditions or those not affected by immune system dysregulation may not benefit from this research.
What this research studies
This research investigates the role of a specific type of immune cell, known as regulatory T cells (Tregs), in the skin and how they help control inflammation and maintain tissue health. The researchers will use advanced techniques to analyze the metabolism of these cells, particularly how they adapt to different environmental signals. By employing innovative methods like single-cell profiling and genetic tools, the study aims to uncover the unique metabolic characteristics of skin Tregs, which could lead to new insights into treating skin-related immune disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for skin conditions characterized by inflammation, such as allergic dermatitis and eczema.
How similar studies have gone: Previous research has shown promising results in understanding Tregs in other tissues, but this specific focus on skin Tregs is relatively novel and untested.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Li, Chaoran — Emory University
- Study coordinator: Li, Chaoran
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.