Understanding how skin fat changes and affects health
Physiological Role of Dedifferentiating Dermal Adipose Tissue
This study is looking at how the fat just under your skin might play a role in fibrosis, a condition that can affect how your body uses energy, and it's using special mouse models to understand how these fat cells can change and possibly cause problems for your health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10992687 on NIH RePORTER |
What this research studies
This research investigates the role of dermal adipose tissue, which is the fat located just beneath the skin, in the development of fibrosis, a condition that can impair metabolic function. The study utilizes advanced genetic mouse models to explore how these fat cells can change their form and function, potentially leading to harmful effects on the body. By examining the dynamic nature of these cells, the research aims to uncover the underlying mechanisms that contribute to fat tissue dysfunction and its systemic consequences.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing metabolic disorders or conditions associated with adipose tissue dysfunction.
Not a fit: Patients who do not have metabolic disorders or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treating conditions related to fat tissue dysfunction, improving metabolic health.
How similar studies have performed: While the specific focus on dermal adipose tissue is relatively novel, similar studies on adipose tissue dynamics have shown promising results in understanding metabolic diseases.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Scherer, Philipp E — Ut Southwestern Medical Center
- Study coordinator: Scherer, Philipp E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.