Understanding how skin cells remember inflammation
Official title: Decoding the mechanism of inflammatory memory in human epithelia
Funded at New York University School of Medicine · NIH-11146864 · Data updated 2026-11-12
This study is looking at how skin cells remember past inflammation, especially in people with psoriasis, to help us understand why flare-ups happen again and again.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AR085932-01 |
| Project ID | NIH-11146864 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of psoriasis or other remitting-relapsing inflammatory skin disorders.
✕Less likely to help
Patients with non-inflammatory skin conditions or those who do not have a history of inflammatory skin diseases may not benefit from this research.
What this research studies
This research investigates how skin cells, specifically epithelial stem and progenitor cells, retain a memory of inflammation, particularly in conditions like psoriasis. By examining the chromatin accessibility and the roles of transcription factors in these cells, the study aims to uncover the mechanisms behind the recurrence of psoriatic lesions. The approach involves using human keratinocyte cultures to analyze how these cells respond to inflammatory signals and how they may become sensitized to future challenges. The goal is to better understand the biological processes that lead to chronic inflammatory conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing relapses in inflammatory skin diseases like psoriasis.
How similar studies have gone: Other research has shown promise in understanding inflammatory memory in various contexts, but this specific approach focusing on human epithelial cells is relatively novel.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Daccache, Joseph — New York University School of Medicine
- Study coordinator: Daccache, Joseph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.