Understanding how skin cells recycle their components to maintain skin health
Official title: Mechanisms of reticulophagy and ER stress mitigation in epidermis
Funded at University of Washington · NIH-10888996 · Data updated 2026-11-12
This study is looking at how skin cells recycle their parts to keep our skin healthy and strong, which could help improve treatments for skin issues like atopic dermatitis.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 15, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $88,250 |
| NIH project number | 5R03AR082896-02 |
| Project ID | NIH-10888996 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from skin conditions like atopic dermatitis or other disorders related to epidermal barrier dysfunction.
✕Less likely to help
Patients with skin conditions unrelated to epidermal barrier dysfunction may not benefit from this research.
What this research studies
This research investigates the processes by which skin cells, specifically keratinocytes, recycle their organelles to maintain the skin's protective barrier. By using advanced techniques like microscopy and gene editing, the researchers aim to uncover the mechanisms that drive the differentiation and degradation of these cells. This knowledge could lead to better treatments for skin conditions related to barrier dysfunction, such as atopic dermatitis. The study focuses on understanding how these processes can be manipulated to improve skin health.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for skin conditions that affect the epidermal barrier, improving the quality of life for patients with these disorders.
How similar studies have gone: Previous research has shown promise in understanding cellular recycling processes in other contexts, suggesting potential for success in this area as well.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Simpson, Cory L — University of Washington
- Study coordinator: Simpson, Cory L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.