Understanding how skin cells interact with the immune system in inflammatory skin diseases
Official title: Disentangling the Epidermal Immune Crosstalk in Inflammatory Skin Disease
Funded at University of California-Irvine · NIH-10925238 · Data updated 2026-11-12
This study is looking at how skin cells and the immune system work together in conditions like psoriasis and atopic dermatitis, with the hope of finding better treatments that are gentler on the body.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $45,458 |
| NIH project number | 5F31AR083279-02 |
| Project ID | NIH-10925238 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from inflammatory skin conditions like psoriasis or atopic dermatitis.
✕Less likely to help
Patients with non-inflammatory skin conditions or those not affected by skin diseases may not benefit from this research.
What this research studies
This research investigates the complex interactions between skin cells and the immune system in conditions like psoriasis and atopic dermatitis. By studying the epidermis, the outer layer of skin, the project aims to uncover how immune responses are regulated and how disruptions can lead to inflammatory skin diseases. The research utilizes animal models to explore the role of specific genes, such as Ovol1, in maintaining skin health and preventing excessive immune cell recruitment. The goal is to develop more effective and targeted treatments that minimize side effects compared to current therapies.
Why it matters
Potential benefit: If successful, this research could lead to new, more effective treatments for inflammatory skin diseases with fewer side effects.
How similar studies have gone: Previous research has shown promise in understanding immune interactions in skin diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Moshensky, Alexander — University of California-Irvine
- Study coordinator: Moshensky, Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.