Understanding how skin cells heal wounds in diabetes
Official title: Epigenetic regulation of keratinocyte function in normal and pathologic skin repair
Funded at University of Michigan at Ann Arbor · NIH-10817026 · Data updated 2026-11-12
This study is looking into why wounds heal slowly for people with Type 2 Diabetes and aims to find ways to help them heal better by focusing on a specific protein that affects inflammation in wounds.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $43,027 |
| NIH project number | 5F31DK136199-02 |
| Project ID | NIH-10817026 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Type 2 Diabetes who experience non-healing wounds.
✕Less likely to help
Patients without Type 2 Diabetes or those with wounds unrelated to diabetes may not benefit from this research.
What this research studies
This research investigates the mechanisms behind impaired wound healing in patients with Type 2 Diabetes (T2D), which can lead to severe complications like amputations. By using both animal models and human samples, the study aims to identify specific genetic factors that affect skin cell function during the healing process. The researchers will focus on a protein called SETDB2, which appears to play a crucial role in regulating inflammation in wounds. The goal is to develop targeted therapies that can improve healing outcomes for patients with T2D.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve wound healing in patients with Type 2 Diabetes.
How similar studies have gone: Previous research has shown promising results in understanding wound healing mechanisms in diabetes, suggesting that this approach could lead to significant advancements.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Moon, Jadie — University of Michigan at Ann Arbor
- Study coordinator: Moon, Jadie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.