Understanding how skin cells divide and orient themselves
Intrinsic and extrinsic spindle orientation mechanisms in mammalian epidermis
This study is looking at how skin stem cells divide and position themselves, which could help us understand skin diseases better and improve treatments for conditions caused by problems with cell division.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11026349 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that control how skin stem cells divide and orient themselves during cell division. By examining both intrinsic and extrinsic factors that influence spindle orientation, the study aims to uncover how these processes affect tissue structure and function. The research utilizes advanced imaging techniques and genetic analysis to observe cell behavior in real-time, providing insights into the balance between cell renewal and differentiation. This knowledge could lead to better understanding of skin diseases and conditions related to abnormal cell division.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with skin conditions related to stem cell dysfunction, such as Acantholysis Bullosa.
Not a fit: Patients with skin conditions not related to stem cell division or those without any skin disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for skin disorders and conditions caused by abnormal cell division.
How similar studies have performed: Previous research has shown promising results in understanding cell division mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Williams, Scott E — Univ of North Carolina Chapel Hill
- Study coordinator: Williams, Scott E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.