Understanding how skin cells contribute to atopic dermatitis
Official title: Fibroblast dysregulation promotes dermal eosinophilic/Th2 inflammation
Funded at University of Pennsylvania · NIH-10932922 · Data updated 2026-11-12
This study is looking at how certain skin cells called fibroblasts might be causing the ongoing inflammation in atopic dermatitis, which could help us understand the condition better and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 21, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $398,151 |
| NIH project number | 5R01AR082951-02 |
| Project ID | NIH-10932922 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with a diagnosis of atopic dermatitis, particularly those experiencing persistent symptoms.
✕Less likely to help
Patients without atopic dermatitis or those with other unrelated skin conditions may not benefit from this research.
What this research studies
This research investigates the role of fibroblasts, a type of skin cell, in the development of atopic dermatitis (AD), a common inflammatory skin condition. By examining how these fibroblasts become dysregulated and contribute to inflammation, the study aims to uncover the mechanisms behind the persistent immune response seen in AD. The researchers will utilize advanced techniques such as ATAC sequencing to analyze changes in gene expression and signaling pathways in skin tissues. This work could lead to new insights into the causes of AD and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from atopic dermatitis.
How similar studies have gone: Previous research has shown promising results in understanding the role of skin cells in atopic dermatitis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Graves, Dana T — University of Pennsylvania
- Study coordinator: Graves, Dana T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.