Understanding how skin barrier function affects health and disease
Insights into skin barrier function: In silico and experimental studies of healthy and diseased stratum corneum lipid models
This study looks at the outer layer of your skin to understand how its structure and fats can affect skin health and conditions like asthma and allergies, with the hope of finding better treatments for these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-10466878 on NIH RePORTER |
What this research studies
This research investigates the skin's outer layer, known as the stratum corneum, which plays a crucial role in protecting against infections, dehydration, and harmful substances. By examining the lipid composition and organization of this layer, the research aims to uncover how these factors contribute to skin diseases and conditions like asthma and allergic rhinitis. The study combines computer modeling and experimental techniques to explore how changes in skin barrier function can impact overall health and treatment effectiveness. Patients may benefit from insights that could lead to improved therapies for skin-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with skin conditions such as atopic dermatitis, allergic rhinitis, or asthma.
Not a fit: Patients with skin conditions unrelated to barrier function or those without any skin issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for skin diseases and related conditions, improving patient quality of life.
How similar studies have performed: Previous research has shown promising results in understanding skin barrier function and its implications for various diseases, indicating that this approach has potential for success.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Laibinis, Paul E — Vanderbilt University
- Study coordinator: Laibinis, Paul E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.