Understanding how skin appendages develop in vertebrates.
Mechanisms of signal transmission in vertebrate skin appendage development.
This study looks at how skin features like hair and glands grow and develop in animals like zebrafish and chickens, hoping to learn more about the genes that control these processes, which could help find new treatments for skin problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11075310 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that control the development of skin appendages, such as hair and glands, using model organisms like zebrafish and chickens. By observing these processes in live animals, researchers aim to uncover how genetic factors influence the formation and patterning of these important structures. The study employs advanced imaging techniques and genetic manipulation to explore cellular behaviors and signaling pathways involved in skin appendage development. Insights gained from this research could lead to new therapeutic strategies for skin disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with congenital or acquired skin appendage disorders.
Not a fit: Patients without skin appendage disorders or those not affected by related genetic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights into treating congenital and acquired skin disorders.
How similar studies have performed: Previous research using similar model systems has successfully advanced our understanding of skin appendage development and its implications for clinical dermatology.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Parichy, David M — University of Virginia
- Study coordinator: Parichy, David M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.