Understanding how skin and nerves interact in atopic dermatitis
Integrin receptor: A connecting link between skin and peripheral sensing neurons in atopic dermatitis
['FUNDING_R01'] · NORTH CAROLINA STATE UNIVERSITY RALEIGH · NIH-10873325
This study is looking at how skin cells and nerve cells work together in kids and teens with atopic dermatitis, which causes intense itching and skin irritation, to find new ways to help relieve that itch.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTH CAROLINA STATE UNIVERSITY RALEIGH (nih funded) |
| Locations | 1 site (RALEIGH, UNITED STATES) |
| Trial ID | NIH-10873325 on ClinicalTrials.gov |
What this research studies
This research investigates the connection between skin cells and sensory neurons in children and adolescents suffering from atopic dermatitis, a condition characterized by severe itching and skin inflammation. The study aims to identify specific signaling pathways that contribute to chronic itch, focusing on molecules like thymic stromal lymphopoietin (TSLP) and the integrin receptor on sensory neurons. By exploring these pathways, the research seeks to uncover new therapeutic targets that could lead to more effective treatments for managing chronic itch associated with atopic dermatitis.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents diagnosed with atopic dermatitis who experience chronic itching.
Not a fit: Patients with atopic dermatitis who do not experience chronic itch may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of innovative treatments that provide long-term relief from chronic itch for patients with atopic dermatitis.
How similar studies have performed: Other research has shown promise in exploring similar signaling pathways in chronic itch, indicating that this approach could yield valuable insights.
Where this research is happening
RALEIGH, UNITED STATES
- NORTH CAROLINA STATE UNIVERSITY RALEIGH — RALEIGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MISHRA, SANTOSH K. — NORTH CAROLINA STATE UNIVERSITY RALEIGH
- Study coordinator: MISHRA, SANTOSH K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.