Understanding how skeletal stem cells adapt in craniofacial bone diseases.
Official title: Skeletal stem cell plasticity in craniofacial bone diseases.
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11017411 · Data updated 2026-11-12
This study is looking at how certain stem cells in the face and jaw adapt to everyday activities like chewing and swallowing, with the goal of understanding bone diseases that can affect dental health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 20, 2024 |
| Project end | June 30, 2032 |
| Funding year | 2024 |
| Award (this year) | $1,027,998 |
| NIH project number | 1R35DE034348-01 |
| Project ID | NIH-11017411 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with craniofacial bone deformities or diseases, particularly those experiencing issues related to bone development and regeneration.
✕Less likely to help
Patients with non-craniofacial bone diseases or those without skeletal stem cell involvement may not benefit from this research.
What this research studies
This research investigates the adaptability of skeletal stem cells in the craniofacial region, focusing on how these cells respond to the functional demands of activities like chewing and swallowing. The study aims to uncover the mechanisms behind craniofacial bone diseases, which are often seen in dental practices, by exploring the dynamic regulation of bone formation throughout life. By examining both intramembranous and endochondral pathways, the research seeks to fill existing knowledge gaps and improve our understanding of craniofacial bone health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments and strategies for managing craniofacial bone diseases, enhancing patient outcomes.
How similar studies have gone: Previous research has shown promise in understanding skeletal stem cell behavior in other contexts, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Ono, Noriaki — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Ono, Noriaki
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.