Understanding how SIV spreads and persists in infected monkeys
Project 2: Analysis of Reservoir Dynamics in SIV-Infected Rhesus Macaques
This study is looking at how a virus similar to HIV behaves in monkeys to help us understand how it hides in the body and how our immune system responds, which could lead to better treatments for people living with HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11079504 on NIH RePORTER |
What this research studies
This research investigates the dynamics of viral reservoirs in rhesus macaques infected with SIV, which is similar to HIV in humans. By using non-human primate models, the study aims to explore how the virus establishes and maintains itself in the body, particularly focusing on immune responses and potential treatment strategies. The researchers will analyze the types of cells involved in the virus's persistence and how these dynamics compare to those observed in people living with HIV. This work could lead to insights that inform future therapies for HIV.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research are individuals living with HIV who are seeking new treatment options.
Not a fit: Patients who are not infected with HIV or SIV will not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for controlling or eradicating HIV in humans.
How similar studies have performed: Previous research using similar non-human primate models has shown promising results in understanding HIV pathogenesis and potential treatment strategies.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Barouch, Dan H. — Johns Hopkins University
- Study coordinator: Barouch, Dan H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.