Understanding how Sirtuin proteins affect tuberculosis and HIV interactions in immune cells
Official title: Sirtuin -Dependent Regulation of Tuberculosis and HIV Interactions in Macrophages
Funded at Methodist Hospital Research Institute · NIH-10947239 · Data updated 2026-11-12
This study is looking at how certain proteins in our immune cells might help us understand and treat people who have both tuberculosis and HIV, with the hope of finding new ways to use medications that target these proteins alongside existing treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,297,775 |
| NIH project number | 1R01AI184551-01 |
| Project ID | NIH-10947239 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and adults living with both tuberculosis and HIV, particularly those who are unable to receive traditional tuberculosis vaccines.
✕Less likely to help
Patients who are not infected with either tuberculosis or HIV may not receive any benefit from this research.
What this research studies
This research investigates the role of Sirtuin proteins in the interactions between tuberculosis and HIV within human macrophages, which are key immune cells. The study aims to understand how these infections influence Sirtuin gene and protein levels and their epigenetic targets. By exploring the potential of Sirtuin-targeting drugs combined with treatments for both tuberculosis and HIV, the researchers hope to develop new immunochemotherapy strategies that could effectively combat these co-infections.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that effectively manage and potentially eradicate both tuberculosis and HIV in affected individuals.
How similar studies have gone: While the approach of targeting Sirtuin proteins in the context of tuberculosis and HIV is innovative, preliminary studies have shown promise in similar areas of research.
Where this research is happening
-
Methodist Hospital Research Institute
Houston, United States Active
Researchers
- Principal investigator: Jagannath, Chinnaswamy — Methodist Hospital Research Institute
- Study coordinator: Jagannath, Chinnaswamy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.