Understanding how SIRT1 is regulated by its N-terminal region
Elucidating the Mechanism for Allosteric Regulation of SIRT1 through the N-terminal Region
This study is looking at how a specific part of the SIRT1 protein works and how different compounds, like resveratrol, can change its activity, which could help develop new treatments for conditions like Alzheimer's disease and diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Jose State University NIH-funded |
| Lab location | 1 site (San Jose, United States) |
| Project ID | NIH-11081679 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the N-terminal region of the SIRT1 protein regulates its activity. SIRT1 is involved in critical biological processes such as insulin secretion and neurodegeneration, making it a potential target for therapies. The study will explore how different compounds, including resveratrol, affect SIRT1's function and stability. By examining these interactions, the research aims to provide insights that could lead to new treatments for conditions like Alzheimer's disease and diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Alzheimer's disease or adult-onset diabetes.
Not a fit: Patients with conditions unrelated to SIRT1 regulation or those not diagnosed with Alzheimer's disease or diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing Alzheimer's disease and diabetes.
How similar studies have performed: Previous research has shown promise in targeting SIRT1 for therapeutic purposes, indicating that this approach may yield valuable insights.
Where this research is happening
San Jose, United States
- San Jose State University — San Jose, United States (Active)
Researchers
- Principal investigator: Wang, Ningkun — San Jose State University
- Study coordinator: Wang, Ningkun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.