Understanding how SIRT1 is regulated by its N-terminal region
Official title: Elucidating the Mechanism for Allosteric Regulation of SIRT1 through the N-terminal Region
Funded at San Jose State University · NIH-11081679 · Data updated 2026-11-12
This study is looking at how a specific part of the SIRT1 protein works and how different compounds, like resveratrol, can change its activity, which could help develop new treatments for conditions like Alzheimer's disease and diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Jose State University NIH-funded |
| Lab location | 1 site (San Jose, United States) |
| Project start | June 5, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $146,500 |
| NIH project number | 5R16GM149377-03 |
| Project ID | NIH-11081679 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Alzheimer's disease or adult-onset diabetes.
✕Less likely to help
Patients with conditions unrelated to SIRT1 regulation or those not diagnosed with Alzheimer's disease or diabetes may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the N-terminal region of the SIRT1 protein regulates its activity. SIRT1 is involved in critical biological processes such as insulin secretion and neurodegeneration, making it a potential target for therapies. The study will explore how different compounds, including resveratrol, affect SIRT1's function and stability. By examining these interactions, the research aims to provide insights that could lead to new treatments for conditions like Alzheimer's disease and diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing Alzheimer's disease and diabetes.
How similar studies have gone: Previous research has shown promise in targeting SIRT1 for therapeutic purposes, indicating that this approach may yield valuable insights.
Where this research is happening
-
San Jose State University
San Jose, United States Active
Researchers
- Principal investigator: Wang, Ningkun — San Jose State University
- Study coordinator: Wang, Ningkun
Related research
Other NIH-funded projects on the same topics.
-
Hormonal limits on heart cell division in mammalian hearts
This grant looks at why adult hearts can’t regrow after injury and explores how hormones, especially thyroid hormone, stop heart cells from dividing to help young hearts regenerate.
-
How the cell’s environment affects p53 and PTEN stability and clumping
This project looks at how the inside of cancer cells might push p53 and PTEN to misfold and form clumps, which could drive cancer progression.
-
Closed-loop Deep Brain Stimulation for Disrupting Abnormal Brain Signals in Alzheimer’s Disease
This grant funds research to test a smart, responsive brain stimulation approach to help people with Alzheimer’s-related brain changes feel fewer symptoms.
-
Diet-Driven Muscle Stem Cell Activation in Fruit-Fly Models
A basic science project aims to understand how diet affects muscle stem cells in a model system and what this could mean for muscle repair and aging in people.
-
Understanding Amyloid Fibril Formation in Diseases Using Space-Based Simulations
Researchers will use advanced computer models to study how tiny protein fibers that cause diseases like Alzheimer’s and type 2 diabetes start forming.
-
High-Definition 3D Printing Tool for Microfluidics at SJSU
A high-definition 3D printer will help San Jose State University researchers and students quickly build microfluidic devices for biology and biomedical education.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.