Understanding how SIRT1 helps cells respond to fluoride exposure in dental health.
Official title: Epigenetic and non-epigenetic role of SIRT1 in fluoride-induced cell stress.
Funded at Nova Southeastern University · NIH-10823889 · Data updated 2026-11-12
This study is looking at how a protein called SIRT1 helps tooth-building cells handle stress from fluoride, which is used to protect teeth, and aims to find new ways to prevent dental fluorosis while keeping fluoride's benefits.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nova Southeastern University NIH-funded |
| Lab location | 1 site (Fort Lauderdale-Davie, UNITED STATES) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $364,493 |
| NIH project number | 7R01DE027648-06 |
| Project ID | NIH-10823889 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are at risk of developing dental fluorosis due to fluoride exposure.
✕Less likely to help
Patients who are not children or those who do not have concerns related to dental fluorosis may not benefit from this research.
What this research studies
This research investigates the role of a protein called SIRT1 in how cells adapt to stress caused by fluoride, which is commonly used to prevent tooth decay. The study focuses on understanding both the epigenetic and non-epigenetic functions of SIRT1 in ameloblasts, the cells responsible for forming tooth enamel. By examining how SIRT1 influences cell survival and autophagy in response to fluoride, the researchers aim to identify potential new treatments to prevent dental fluorosis while maintaining the benefits of fluoride in public water. The research involves laboratory experiments using cultured cell lines to explore these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing dental fluorosis in children while still allowing the use of fluoride to combat tooth decay.
How similar studies have gone: While the specific role of SIRT1 in fluoride-induced stress responses is being explored for the first time, similar research has shown promise in understanding cellular responses to environmental stressors.
Where this research is happening
-
Nova Southeastern University
Fort Lauderdale-Davie, United States Active
Researchers
- Principal investigator: Suzuki, Maiko — Nova Southeastern University
- Study coordinator: Suzuki, Maiko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.