Understanding how single-cell genetics relate to type 2 diabetes in young people
Official title: Mapping Integrated Single-Cell Chromatin Accessibility with the Single-Cell Transcriptional Landscape in Pediatric Type 2 Diabetes
Funded at Emory University · NIH-11082215 · Data updated 2026-11-12
This study is looking at the genes and molecules that might cause type 2 diabetes in young people under 21, with the goal of finding new ways to prevent and treat the condition by understanding how different immune cells play a role.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $151,902 |
| NIH project number | 5K01DK133669-03 |
| Project ID | NIH-11082215 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are youth under 21 years old who are at risk for or diagnosed with type 2 diabetes.
✕Less likely to help
Patients over the age of 21 or those without type 2 diabetes may not benefit from this research.
What this research studies
This research investigates the genetic and molecular factors contributing to type 2 diabetes (T2D) in individuals under 21 years of age. By using advanced techniques to analyze single-cell chromatin accessibility and transcription factors, the study aims to identify new targets for prevention and treatment of T2D. It combines laboratory work with bioinformatics, including machine learning, to integrate various data types and classify different T2D phenotypes. The research also focuses on understanding the roles of different immune cell types in the disease process, which could lead to more personalized treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new prevention and treatment strategies for type 2 diabetes in young individuals.
How similar studies have gone: Previous research has shown promise in using single-cell techniques to understand complex diseases, suggesting potential success for this approach.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Staimez, Lisa Rachel — Emory University
- Study coordinator: Staimez, Lisa Rachel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.