Understanding how silencers control T cell function
Silencer Control of T cell Homeostasis
['FUNDING_FELLOWSHIP'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-10982456
This study is looking at special parts of our DNA that help control how certain immune cells, called CD4+ T cells, work, and it aims to find out how these parts can affect our immune responses, which could help us understand and treat diseases related to these cells better.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-10982456 on ClinicalTrials.gov |
What this research studies
This research investigates the role of non-coding DNA sequences, known as silencers, in regulating the function of human T cells, specifically CD4+ T cells. The project aims to identify these functional silencers and understand how they influence gene expression in T cells, which is crucial for maintaining immune responses. By employing advanced techniques to screen for these silencers, the research seeks to uncover their mechanisms of action and their contributions to T cell homeostasis. This could lead to new insights into immune system regulation and potential therapeutic targets for diseases involving T cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that affect T cell function, such as autoimmune diseases or certain cancers.
Not a fit: Patients with conditions unrelated to T cell function or those who do not have active immune system disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of T cell regulation, potentially leading to improved treatments for immune-related conditions and cancers.
How similar studies have performed: While the study of enhancers in gene regulation has been well-established, the investigation of silencers is relatively novel, indicating a potential for groundbreaking findings in this area.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STEFAN, KURTIS — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: STEFAN, KURTIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.