Understanding how signals shape organ formation
Establishing the effect of morphogens at the supracellular scale during organ formation
['FUNDING_R01'] · ROCKEFELLER UNIVERSITY · NIH-11000826
This study is looking at how certain signals help groups of cells work together to shape organs, and the findings could lead to better treatments for conditions related to organ development.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROCKEFELLER UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11000826 on ClinicalTrials.gov |
What this research studies
This research investigates how specific signals, known as morphogens, influence the behavior of groups of cells during the formation of organs. By examining how these signals affect the physical properties of tissues, the study aims to uncover the mechanisms behind the complexity of organ shapes. The approach involves using advanced assays to observe and analyze the collective behavior of cells, linking molecular events to larger-scale organ development. Patients may benefit from insights gained about organ formation, which could inform future treatments for developmental disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with congenital anomalies or developmental disorders affecting organ structure.
Not a fit: Patients with fully developed organs and no history of congenital or developmental issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of birth defects and other conditions related to organ formation.
How similar studies have performed: Previous research has shown promising results in understanding cellular behavior and organ development, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- ROCKEFELLER UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHYER, AMY ELIZABETH — ROCKEFELLER UNIVERSITY
- Study coordinator: SHYER, AMY ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.