Understanding how signals shape organ formation
Official title: Establishing the effect of morphogens at the supracellular scale during organ formation
Funded at Rockefeller University · NIH-11000826 · Data updated 2026-11-12
This study is looking at how certain signals help groups of cells work together to shape organs, and the findings could lead to better treatments for conditions related to organ development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $305,100 |
| NIH project number | 5R01GM152611-02 |
| Project ID | NIH-11000826 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with congenital anomalies or developmental disorders affecting organ structure.
✕Less likely to help
Patients with fully developed organs and no history of congenital or developmental issues may not receive direct benefits from this research.
What this research studies
This research investigates how specific signals, known as morphogens, influence the behavior of groups of cells during the formation of organs. By examining how these signals affect the physical properties of tissues, the study aims to uncover the mechanisms behind the complexity of organ shapes. The approach involves using advanced assays to observe and analyze the collective behavior of cells, linking molecular events to larger-scale organ development. Patients may benefit from insights gained about organ formation, which could inform future treatments for developmental disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of birth defects and other conditions related to organ formation.
How similar studies have gone: Previous research has shown promising results in understanding cellular behavior and organ development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Shyer, Amy Elizabeth — Rockefeller University
- Study coordinator: Shyer, Amy Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.