Understanding how signals from tissues influence the development of sensory neurons.
Deciphering Trophic Signaling Programs Governing Peripheral Sensory Nervous System Development
This study is looking at how certain proteins help nerve cells in your body grow and change so they can better sense things like touch and pain, which could help us understand more about how we feel sensations and manage pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10756980 on NIH RePORTER |
What this research studies
This research investigates how sensory neurons in the peripheral nervous system develop and differentiate into various types, which are essential for sensing different environmental stimuli. It focuses on the role of neurotrophic factors, which are proteins that influence the growth and survival of neurons, in guiding these developmental processes. By examining how these factors interact with specific receptors on neuron progenitors, the research aims to uncover the mechanisms that determine the fate of these sensory neurons. This could lead to a better understanding of sensory processing and pain perception.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting sensory perception or pain sensitivity.
Not a fit: Patients with established sensory nerve damage that is not related to developmental factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating sensory disorders and improving pain management.
How similar studies have performed: Previous research has shown promising results in understanding neurotrophic factors and their role in nerve development, suggesting that this approach has potential for success.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Zunder, Eli — University of Virginia
- Study coordinator: Zunder, Eli
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.