Understanding how signals from the cell surface affect eye development in vertebrates
Official title: Morphogenetic signaling from the cell surface to the nucleus during vertebrate eye development
Funded at University of Utah · NIH-10882991 · Data updated 2026-11-12
This study is looking at how certain signals help the eye develop properly, and it hopes to find new ways to treat eye problems that happen when these signals go wrong, which could help patients with developmental eye conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $714,141 |
| NIH project number | 1R01EY035377-01A1 |
| Project ID | NIH-10882991 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital eye disorders linked to misregulated Hedgehog signaling.
✕Less likely to help
Patients with eye conditions unrelated to developmental signaling pathways may not benefit from this research.
What this research studies
This research investigates the Hedgehog signaling pathway, which is crucial for the proper development of the eye in vertebrates. It focuses on how signals from the cell surface are transmitted to the nucleus, influencing various developmental processes. By studying the interactions between specific proteins involved in this signaling pathway, the research aims to uncover mechanisms that could lead to new treatments for eye disorders caused by misregulated signaling. Patients may benefit from insights gained that could inform therapeutic strategies for developmental eye conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating developmental eye disorders.
How similar studies have gone: Previous research has shown promising results in understanding similar signaling pathways and their implications for developmental disorders.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Myers, Benjamin — University of Utah
- Study coordinator: Myers, Benjamin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.