Understanding how signals control stem cell activity in tissues
Intrinsic and extrinsic control of epithelial tissue stem cell activity
This study is looking at how certain signals and genes affect the behavior of stem cells in the skin and mammary glands, which could help improve treatments for healing and tissue repair in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11045752 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate the activity of epithelial tissue stem cells, which are crucial for tissue maintenance and regeneration. By studying mammary gland and skin tissues, the research aims to uncover how intrinsic genetic factors and external signals from the surrounding environment influence stem cell behavior. The goal is to gain insights that could lead to advancements in tissue engineering and regenerative medicine, potentially allowing for better manipulation of cell fates in therapeutic contexts.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions affecting epithelial tissues, such as breast cancer or skin disorders.
Not a fit: Patients with non-epithelial tissue conditions or those not requiring regenerative therapies may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for tissue regeneration and repair, benefiting patients with conditions related to tissue damage or degeneration.
How similar studies have performed: Previous research has shown success in understanding stem cell regulation and its implications for regenerative medicine, indicating that this approach is built on established scientific foundations.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Dai, Xing — University of California-Irvine
- Study coordinator: Dai, Xing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.