Understanding how signals affect nerve cell development and degeneration.
Official title: Long distance regressive signaling underlies sculpting of the nervous system during development.
Funded at Vanderbilt University · NIH-11047331 · Data updated 2026-11-12
This study is looking at how certain signals in the nervous system can cause nerve cells to die, which might help us understand conditions like autism and Alzheimer's disease better, and it could lead to new ways to treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $543,337 |
| NIH project number | 1R01NS136342-01A1 |
| Project ID | NIH-11047331 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with neurodevelopmental disorders like autism or neurodegenerative diseases such as Alzheimer's or ALS.
✕Less likely to help
Patients with acute neurological injuries or those not diagnosed with the targeted neurodevelopmental or neurodegenerative conditions may not benefit from this research.
What this research studies
This research investigates the mechanisms of long-distance signaling in the nervous system, focusing on how certain signals can lead to nerve cell death and degeneration. By studying the p75 neurotrophin receptor, the research aims to uncover how these signals are transmitted from nerve endings back to the cell body. This could provide insights into various neurodevelopmental and neurodegenerative disorders, including autism and Alzheimer's disease. The approach involves examining the molecular processes that regulate these signaling pathways, which could lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodevelopmental and neurodegenerative disorders.
How similar studies have gone: Previous research has shown promising results in understanding similar signaling pathways, indicating potential for success in this area.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Carter, Bruce D — Vanderbilt University
- Study coordinator: Carter, Bruce D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.