Understanding how signals affect eye development
Signal Integration During Eye Formation
This study is looking at how two key processes in our cells, called Notch and Hedgehog, work together when the eye is developing, which could help us understand and treat certain eye diseases that people are born with.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10666489 on NIH RePORTER |
What this research studies
This research investigates how two important signaling pathways, Notch and Hedgehog (Hh), interact during the development of the eye. By using advanced techniques such as mouse genetics and stem cell-derived retinal organoids, the study aims to uncover the mechanisms that lead to congenital eye diseases. The researchers will explore how these pathways influence cell growth, differentiation, and the overall formation of eye structures during embryonic development. This work could provide insights into the causes of eye abnormalities and potential therapeutic approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital eye disorders such as anophthalmia or coloboma.
Not a fit: Patients with acquired eye conditions unrelated to developmental processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for congenital eye diseases and improve understanding of eye development.
How similar studies have performed: Previous research has shown promising results in understanding signaling pathways in development, suggesting potential for breakthroughs in this area.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Brown, Nadean L — University of California at Davis
- Study coordinator: Brown, Nadean L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.