Understanding how signaling pathways control cell differentiation in fruit flies.
Official title: Systems-level Analysis of Dynamics and Regulation of the Drosophila NF-kappaB/Dorsal Signaling Module
Funded at Texas Engineering Experiment Station · NIH-10982239 · Data updated 2026-11-12
This study is looking at how certain signals in fruit fly embryos help cells make important decisions about their development, using special imaging techniques to see how these signals work together, which could help us understand similar processes in other living things, including humans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Engineering Experiment Station NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | September 21, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $335,504 |
| NIH project number | 1R01GM151409-01A1 |
| Project ID | NIH-10982239 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research would be individuals with conditions related to cellular differentiation and signaling pathways.
✕Less likely to help
Patients with conditions unrelated to cellular signaling or differentiation may not receive any benefit from this research.
What this research studies
This research investigates the dynamics and regulation of the NF-kappaB/Dorsal signaling module in Drosophila embryos, focusing on how these pathways influence cellular decision-making and differentiation. By using advanced quantitative imaging techniques, the study aims to measure the interactions and concentrations of signaling proteins in live cells. The goal is to develop predictive models that can explain how these signaling pathways operate, particularly in the context of feedback loops that affect gene expression. This work could provide insights into fundamental biological processes that are relevant to various developmental and disease contexts.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cellular differentiation, potentially leading to new therapeutic strategies for diseases related to cell signaling.
How similar studies have gone: While this research employs established techniques, the specific application to the NF-kappaB/Dorsal signaling module in Drosophila is relatively novel and has not been extensively tested.
Where this research is happening
-
Texas Engineering Experiment Station
College Station, United States Active
Researchers
- Principal investigator: Reeves, Gregory T — Texas Engineering Experiment Station
- Study coordinator: Reeves, Gregory T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.