Understanding how signaling mechanisms help maintain genome stability
Signaling Mechanisms in Genome Maintenance
This study is looking at how certain proteins help fix DNA and keep cells healthy, which could lead to better cancer treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11056744 on NIH RePORTER |
What this research studies
This research investigates the complex signaling networks that coordinate DNA repair and the cell cycle, focusing on specific kinases that play a crucial role in maintaining genome integrity. By exploring the functions of phosphatidylinositol 3′ kinase-related kinases (PIKKs), the study aims to uncover new mechanisms of DNA repair regulation and how these kinases affect cancer cell viability. The research employs advanced proteomic techniques to identify key proteins involved in DNA synthesis and repair, which could lead to improved cancer therapies. Patients may benefit from insights gained through this research, particularly in the context of targeted cancer treatments.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic predispositions to cancer or those currently undergoing cancer treatment.
Not a fit: Patients with non-cancerous conditions or those not affected by genetic disorders related to DNA repair may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer therapies by enhancing our understanding of DNA repair mechanisms.
How similar studies have performed: Previous research has shown success in utilizing similar signaling mechanisms to develop targeted cancer therapies, indicating a promising avenue for further exploration.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Smolka, Marcus — Cornell University
- Study coordinator: Smolka, Marcus
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.