Understanding how sickness affects sleep and behavior in worms
Mechanistic studies of sickness sleep
This study is looking at how being sick affects sleep and behavior in tiny worms called C. elegans, to help us understand how certain factors, like a special growth factor, might play a role in sleepiness when we're ill and how sleep can help us recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10871681 on NIH RePORTER |
What this research studies
This research investigates how sickness influences sleep and behavior in the nematode C. elegans, a model organism. By exposing these worms to various stressors like heat and ultraviolet light, the study aims to uncover the mechanisms behind sickness-induced behaviors, particularly focusing on the role of the epidermal growth factor (EGF). The researchers will identify when and where EGF is released in the worms and explore other genes that may regulate sickness behavior. Ultimately, the goal is to find potential targets for developing treatments for sleepiness during illness and to understand how sleep aids recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of sleep and sickness, particularly those affected by conditions that cause excessive sleepiness.
Not a fit: Patients with conditions unrelated to sleep disturbances or sickness behaviors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostics and treatments for sleep-related issues during illness.
How similar studies have performed: Other research has shown success in understanding sickness behaviors in various organisms, suggesting that this approach may yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Raizen, David Menassah — University of Pennsylvania
- Study coordinator: Raizen, David Menassah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.