Understanding how sialic acid and sialidase affect gum disease caused by Porphyromonas gingivalis
Dissecting the role of sialic acid and sialidase in the pathophysiology of Porphyromonas gingivalis
This study is looking at how certain substances in your saliva might affect gum disease caused by specific bacteria, with the hope of finding new ways to treat and manage periodontitis for people who are dealing with it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-11017599 on NIH RePORTER |
What this research studies
This research investigates the role of sialic acid and sialidase in the development of periodontitis, a serious gum disease linked to the bacteria Porphyromonas gingivalis. It explores how these components interact with the immune system and contribute to the bacteria's ability to thrive in the mouth. By analyzing the presence of sialic acid in saliva and its relationship with gum health, the study aims to identify potential biomarkers for periodontitis severity. Patients may benefit from insights that could lead to new treatment strategies for gum disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing symptoms of gum disease or those diagnosed with periodontitis.
Not a fit: Patients without any signs of gum disease or those who have already undergone extensive treatment for periodontitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatments for periodontitis, enhancing oral health and potentially reducing the risk of related systemic diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of sialic acid in oral health, indicating that this approach could yield valuable insights.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Li, Chunhao Chris — Virginia Commonwealth University
- Study coordinator: Li, Chunhao Chris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.