Understanding how SHIP1 regulates immune cell behavior
Deciphering the mechanism of SHIP1 regulation in human neutrophils
This study is looking at how a type of immune cell called neutrophils reacts to signals in the body, focusing on a protein called SHIP1 that helps these cells move toward where they're needed, which is important for fighting off infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project ID | NIH-11087533 on NIH RePORTER |
What this research studies
This research investigates how human neutrophils, a type of immune cell, respond to chemical signals in their environment. It focuses on the role of a specific protein, SHIP1, in controlling the communication between various signaling molecules at the cell membrane. By using advanced techniques like single molecule imaging and biochemistry methods, the study aims to uncover the mechanisms that govern how neutrophils polarize and migrate towards signals, which is crucial for immune responses. The findings could provide insights into the fundamental processes of immune cell behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve immune system dysfunction or those who are interested in understanding immune responses.
Not a fit: Patients with stable immune conditions or those not affected by immune system-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses in patients, potentially improving treatments for infections and inflammatory diseases.
How similar studies have performed: Other research has shown promising results in understanding immune cell signaling, indicating that this approach has the potential for significant findings.
Where this research is happening
Eugene, United States
- University of Oregon — Eugene, United States (Active)
Researchers
- Principal investigator: Hansen, Scott David — University of Oregon
- Study coordinator: Hansen, Scott David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.