Understanding how Shigella bacteria cause disease using a new mouse model
Dissection of Shigella pathogenesis in vivo using a new oral infection mouse model
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-10910911
This study is looking at how Shigella bacteria make people sick by using special mice that act like humans, and it aims to learn how our immune system fights back, which could help us find better ways to prevent and treat Shigella infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-10910911 on ClinicalTrials.gov |
What this research studies
This research investigates how Shigella bacteria infect humans and cause illness by using a newly developed mouse model that mimics human infection. The study focuses on understanding the immune responses in these mice, particularly how certain immune cells react to the bacteria. By examining both the innate and adaptive immune responses, researchers aim to uncover the mechanisms behind Shigella's ability to evade the immune system. This could lead to better prevention and treatment strategies for Shigella infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of Shigella infections, particularly those in areas with high rates of transmission.
Not a fit: Patients who are not at risk of Shigella infections or those who have already been vaccinated against it may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for Shigella infections, which are a significant cause of diarrhea worldwide.
How similar studies have performed: Previous research has shown success in using animal models to study bacterial infections, making this approach promising for understanding Shigella pathogenesis.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VANCE, RUSSELL E — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: VANCE, RUSSELL E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.