Understanding how Shigella bacteria affect intestinal cells
Official title: Shigella mediated regulation of epithelial cell inflammasomes
Funded at Tufts University Boston · NIH-11060922 · Data updated 2026-11-12
This study is looking at how the Shigella bacteria trick our gut cells to survive and make us sick, which could help us find better ways to treat infections, especially those that don't respond to antibiotics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 14, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $752,519 |
| NIH project number | 7R01AI169795-03 |
| Project ID | NIH-11060922 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced Shigella infections or are at risk of such infections, especially in areas with high rates of antibiotic resistance.
✕Less likely to help
Patients who do not have a history of Shigella infection or are not at risk for such infections may not benefit from this research.
What this research studies
This research investigates how Shigella, a highly infectious bacterium, manipulates intestinal epithelial cells to survive and cause disease. By examining the interactions between Shigella and host cells, the study aims to uncover the mechanisms that allow these pathogens to evade the immune response and establish infection. The research utilizes advanced techniques to analyze the behavior of Shigella within the cells and the resulting inflammatory responses. This could lead to new insights into treating infections caused by antibiotic-resistant strains.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for Shigella infections, particularly those that are resistant to antibiotics.
How similar studies have gone: Previous research has shown success in understanding bacterial pathogenesis and immune evasion, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Tufts University Boston
Boston, United States Active
Researchers
- Principal investigator: Lesser, Cammie — Tufts University Boston
- Study coordinator: Lesser, Cammie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.