Understanding how shadow enhancers help genes function during development
Mechanisms of shadow enhancer robustness during development
This study is looking at special parts of our DNA that help control how our genes work during development, to understand how they keep things on track even when there are challenges, and it could help explain why some genetic changes lead to conditions like autism while others don’t.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University (Charles River Campus) NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11127880 on NIH RePORTER |
What this research studies
This research investigates the role of shadow enhancers, which are groups of regulatory elements that help control gene expression during development. By studying how these enhancers work in various organisms, including humans, the research aims to uncover how they maintain normal development despite genetic and environmental challenges. The approach includes systematic surveys and experimental models to analyze the robustness of these enhancers and their impact on developmental diseases like autism. The findings could provide insights into why certain genetic mutations lead to disorders while others do not.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autism spectrum disorder or those interested in the genetic underpinnings of developmental conditions.
Not a fit: Patients with developmental disorders not linked to genetic mutations or environmental factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic factors contributing to developmental disorders, potentially informing new treatment strategies.
How similar studies have performed: Previous research has shown success in understanding gene regulation through enhancer studies, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
Boston, United States
- Boston University (Charles River Campus) — Boston, United States (Active)
Researchers
- Principal investigator: Wunderlich, Zeba B — Boston University (Charles River Campus)
- Study coordinator: Wunderlich, Zeba B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.