Understanding how sexual identity affects gene expression in germ cells
Official title: Investigating how germline sexual identity controls sex-specific gene expression
Funded at Johns Hopkins University · NIH-11071207 · Data updated 2026-11-12
This study looks at how certain cells in fruit flies decide whether they become male or female and how this choice affects their genes, focusing on a specific protein that helps with this process.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | November 1, 2024 |
| Project end | October 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31HD115364-01A1 |
| Project ID | NIH-11071207 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to sexual identity or fertility issues, particularly those who are affected by genetic factors.
✕Less likely to help
Patients who do not have concerns related to sexual identity or reproductive health may not benefit from this research.
What this research studies
This research investigates the mechanisms by which germ cells determine their sexual identity and how this affects gene expression. It focuses on the role of the RNA binding protein Sex lethal (Sxl) and its influence on the expression of a gene called Tdrd5l, which is crucial for male germline identity. By studying the interactions between germline and somatic signals, the research aims to uncover the complex regulatory pathways involved in sex determination. This work utilizes Drosophila as a model organism to explore these biological processes.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of sexual identity determination, potentially leading to advancements in reproductive health and fertility treatments.
How similar studies have gone: While the specific approach of this research is novel, there have been successful studies exploring gene expression and sexual identity in other contexts.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Curnutte, Harrison — Johns Hopkins University
- Study coordinator: Curnutte, Harrison
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.