Understanding how sex-linked genes and a specific genetic risk factor affect Alzheimer's disease
Dissecting the role of sex-linked genes and APOE e4 risk in AD
This study is looking at how being male or female might affect the risk and progression of Alzheimer's disease, especially focusing on certain genes, to help find better treatments and understand how genetics play a role in the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10892895 on NIH RePORTER |
What this research studies
This research investigates the differences in Alzheimer's disease (AD) risk and progression between men and women, particularly focusing on the role of sex-linked genes and the APOEɛ4 allele, a known genetic risk factor. The study aims to explore how these genetic factors influence neuroinflammation and disease progression using advanced cellular models and human tissue samples. By analyzing the impact of sex chromosomes and specific genes, the research seeks to uncover new insights into the biological mechanisms behind AD, which could lead to more targeted treatments. Patients may benefit from a better understanding of their genetic risk and potential interventions based on their sex and genetic profile.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Alzheimer's disease, particularly women who carry the APOEɛ4 allele.
Not a fit: Patients who do not have a genetic predisposition to Alzheimer's disease or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating Alzheimer's disease based on genetic and sex-specific factors.
How similar studies have performed: While there has been research on genetic factors in Alzheimer's disease, this specific focus on sex-linked genes and their interaction with APOEɛ4 is relatively novel and untested.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Young, Jessica Elaine — University of Washington
- Study coordinator: Young, Jessica Elaine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.