Understanding how sex differences in liver cells affect fatty liver disease
Characterizing zonated hepatocyte sexual dimorphism and its role in fatty liver disease
This study looks at how male and female liver cells are different and how those differences might affect the severity of fatty liver disease, with the hope of finding better, more personalized treatments for patients based on their sex.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11011311 on NIH RePORTER |
What this research studies
This research investigates how differences between male and female liver cells contribute to the severity and outcomes of fatty liver disease. It focuses on the liver's structure and function, particularly how these differences vary across different regions of the liver. By examining the genetic and functional variations in liver cells, the study aims to uncover the mechanisms behind these sex-based differences and their implications for liver disease. Patients may benefit from insights that could lead to more personalized treatment approaches based on sex.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with non-alcoholic fatty liver disease, particularly those who are aware of their sex and age-related health factors.
Not a fit: Patients with liver diseases unrelated to sex differences or those who do not have non-alcoholic fatty liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for fatty liver disease that take into account sex differences.
How similar studies have performed: Other research has shown that understanding sex differences in biological systems can lead to significant advancements in treatment strategies, suggesting this approach has potential for success.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Wang, Bruce Mao Zheng — University of California, San Francisco
- Study coordinator: Wang, Bruce Mao Zheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.