Understanding how sex differences affect psychosis in children and adolescents
Official title: Sex-Specific Psychosis Biotypes: Informed Data-driven Neurobiological and Genomic Markers for Early Risk Detection
Funded at Georgia State University · NIH-11050594 · Data updated 2026-11-12
This study is looking at how psychosis shows up differently in boys and girls to help find it earlier and create better treatments, focusing on young people aged 0-20.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia State University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | December 13, 2024 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $525,048 |
| NIH project number | 1R01MH136665-01A1 |
| Project ID | NIH-11050594 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and adolescents aged 0-20 who may be at risk for developing psychotic disorders.
✕Less likely to help
Patients who are older than 20 or those who do not exhibit any risk factors for psychotic disorders may not benefit from this research.
What this research studies
This research investigates the differences in how psychosis manifests in boys and girls, focusing on early detection and tailored interventions. By analyzing brain connectivity and genetic markers in a large group of individuals aged 0-20, the study aims to identify distinct subgroups of psychosis that vary by sex. The approach combines advanced data analysis techniques to uncover biological differences that could lead to better treatment strategies. Ultimately, the goal is to improve outcomes for young people at risk of developing psychotic disorders.
Why it matters
Potential benefit: If successful, this research could lead to more effective early detection and personalized treatment options for young individuals at risk of psychosis.
How similar studies have gone: Previous research has shown promise in identifying sex-specific differences in mental health conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Georgia State University
Atlanta, United States Active
Researchers
- Principal investigator: Iraji, Armin — Georgia State University
- Study coordinator: Iraji, Armin
Related research
Other NIH-funded projects on the same topics.
-
Psychosis in diverse settings across the world
This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.
-
Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.
-
A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
-
Genetic clues for early-onset psychosis in Latino youth
This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.
-
Biomarkers to tailor rehab for Veterans with schizophrenia
A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.
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Computational analysis of facial expression in early psychosis
Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.