Understanding how sex differences affect lung injury in premature infants
Mechanisms of sex differences in neonatal pulmonary oxygen toxicity
This study is looking into why premature baby boys are more likely to develop a serious lung problem called bronchopulmonary dysplasia, and it aims to find out how high oxygen levels after birth affect their lungs differently than baby girls' lungs, which could help create better treatments for these little ones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10641771 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind why premature male infants are more susceptible to bronchopulmonary dysplasia (BPD), a serious lung condition. It focuses on how exposure to high levels of oxygen after birth impacts lung development differently in male and female neonates. By studying neonatal mice, the research aims to uncover the role of specific microRNAs and genetic factors that may protect female lungs from damage caused by oxygen exposure. The findings could lead to targeted therapies that improve lung health in premature infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants, particularly those who are at risk of developing bronchopulmonary dysplasia due to oxygen exposure.
Not a fit: Patients who are not premature or do not have a risk of bronchopulmonary dysplasia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for bronchopulmonary dysplasia in premature infants.
How similar studies have performed: Other research has shown promising results in understanding sex differences in neonatal health, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Lingappan, Krithika — Children's Hosp of Philadelphia
- Study coordinator: Lingappan, Krithika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.