Understanding how sex differences affect inflammation in gum disease
Inflammasome regulation underlying sexual dimorphism in periodontitis
This study is looking at how certain proteins that cause inflammation might affect gum disease differently in men and women, especially for those with severe cases that lead to tooth loss, to help find better treatments for people who don’t get better with regular care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11009953 on NIH RePORTER |
What this research studies
This research investigates the role of inflammasomes, which are protein complexes involved in inflammation, in the development of periodontitis, a common gum disease that affects bone and tissue supporting teeth. The study aims to explore how these inflammasomes function differently in males and females, particularly in patients who experience severe inflammation leading to tooth loss. By examining the biological mechanisms at play, the research seeks to identify potential new therapies for those who do not respond to standard treatments. Patients may be involved in the research to help clarify these differences and contribute to the development of targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals diagnosed with periodontitis, particularly those experiencing severe inflammation or tooth loss.
Not a fit: Patients with mild periodontitis or those who do not have a significant inflammatory response may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for periodontitis that are tailored based on biological sex, improving outcomes for patients suffering from this condition.
How similar studies have performed: Previous research has shown that targeting inflammasome pathways can be effective in treating other inflammatory diseases, suggesting potential for success in this area as well.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Marchesan, Julie Teresa — Univ of North Carolina Chapel Hill
- Study coordinator: Marchesan, Julie Teresa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.