Understanding how sex differences affect heart recovery after a heart attack
Official title: Sex differences in cardiac autonomic remodeling after myocardial infarction
Funded at University of California Los Angeles · NIH-10993635 · Data updated 2026-11-12
This study is looking at how men and women recover differently after a heart attack, especially how hormones like estrogen might affect heart health and rhythm, with the goal of creating better, personalized treatments for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $634,697 |
| NIH project number | 5R01HL170626-02 |
| Project ID | NIH-10993635 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced a myocardial infarction, particularly women and men of varying ages.
✕Less likely to help
Patients who have not had a heart attack or those with non-cardiac related health issues may not benefit from this research.
What this research studies
This research investigates the differences between men and women in how their hearts recover after a heart attack, specifically focusing on the role of the autonomic nervous system. It aims to uncover the mechanisms behind these differences, particularly how sex hormones like estrogen may influence heart function and the risk of dangerous heart rhythms. By studying these factors, the research seeks to develop more personalized treatments for patients based on their sex. Patients may be monitored for changes in heart function and nerve signaling after a heart attack.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored treatments for heart attack recovery based on a patient's sex.
How similar studies have gone: Previous research has indicated that understanding sex differences in cardiovascular health can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Vaseghi, Marmar — University of California Los Angeles
- Study coordinator: Vaseghi, Marmar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.