Understanding how sex differences affect brain development in autism.
Molecular Mechanisms Underlying the sex-Depended Maturation of Modulatory Systems.
This study looks at why autism spectrum disorder (ASD) affects more boys than girls by exploring how certain brain cells, which help with social behavior, develop differently in males and females, using animal models to better understand these differences.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10892119 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that contribute to the differences in autism spectrum disorder (ASD) prevalence between males and females. It focuses on serotonergic neurons and their role in brain functions related to social behavior, particularly how these systems develop differently based on sex. By examining specific proteins involved in synapse formation, the study aims to uncover how these differences may influence social behaviors in individuals with ASD. The research utilizes animal models to explore these biological processes and their implications for understanding ASD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, particularly those who are male.
Not a fit: Patients who do not have autism spectrum disorder or those who are not affected by sex-dependent developmental issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that address the unique developmental pathways of autism in males and females.
How similar studies have performed: Previous research has shown promising results in understanding sex differences in neurodevelopmental disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Futai, Kensuke — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Futai, Kensuke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.