Understanding how sex differences affect blood vessel growth regulation
Official title: Mechanistic basis of sexual dimorphism in antigen-independent IgG1 angiogenesis regulation
Funded at University of Virginia · NIH-11017794 · Data updated 2026-11-12
This study looks at how being male or female affects the way our bodies grow new blood vessels, especially in conditions like Alzheimer's disease, to help find better treatments that work for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | April 1, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $592,328 |
| NIH project number | 5R01HL164592-03 |
| Project ID | NIH-11017794 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related vascular conditions, particularly those interested in how sex may influence their treatment.
✕Less likely to help
Patients with conditions unrelated to angiogenesis or those not diagnosed with Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates how sex influences the regulation of blood vessel growth, particularly in conditions like Alzheimer's disease and other vascular disorders. It aims to explore the mechanisms behind these differences, focusing on the role of specific genes and antibodies in this process. By examining human cells and specimens, the study seeks to clarify how male and female bodies respond differently to angiogenesis, which is crucial for developing targeted treatments. Patients may benefit from insights that could lead to more effective therapies tailored to their sex.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for vascular diseases that consider sex differences.
How similar studies have gone: Previous research has shown that understanding sex differences in disease mechanisms can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Gelfand, Bradley David — University of Virginia
- Study coordinator: Gelfand, Bradley David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.