Understanding how sex differences affect Alzheimer's disease and finding new treatment targets
Sex-specific Molecular Profiling to Understand Pathology and Identify Causal Genes and Drug Targets for Alzheimer's Disease
This study is looking at how Alzheimer's disease affects men and women differently at a genetic level, hoping to find new ways to prevent and treat the disease that are better suited for each gender.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10891769 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular differences in Alzheimer's disease (AD) between men and women. By analyzing various biological data from multiple tissues, the study aims to uncover how these differences influence the risk and progression of AD. The researchers will focus on identifying specific genes and biological pathways that could serve as new targets for drug development. This comprehensive approach could lead to more effective prevention and treatment strategies tailored to each sex.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, particularly women who may be at higher risk.
Not a fit: Patients without a diagnosis of Alzheimer's disease or those who do not have a genetic predisposition to the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve outcomes for individuals with Alzheimer's disease.
How similar studies have performed: Previous research has shown success in identifying genetic factors in Alzheimer's disease, but this study's focus on sex-specific molecular profiling is a novel approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Sung, Yunju — Washington University
- Study coordinator: Sung, Yunju
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.