Understanding how sex chromosomes evolve and affect genetic disorders.
Integrating theory, genomics, and comparative approaches to break barriers to the understanding of genome structure and sex chromosome evolution.
['FUNDING_OTHER'] · TEXAS A&M UNIVERSITY · NIH-10879088
This study looks at how our genes change over time, especially focusing on the differences between regular chromosomes and those that determine sex, to help us understand genetic conditions like Klinefelter syndrome, which could lead to better ways to diagnose and treat these issues for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS A&M UNIVERSITY (nih funded) |
| Locations | 1 site (COLLEGE STATION, UNITED STATES) |
| Trial ID | NIH-10879088 on ClinicalTrials.gov |
What this research studies
This research investigates the evolution of genome structure, focusing on the differences between autosomes and sex chromosomes. By using a combination of comparative, genomic, and theoretical methods, the project aims to uncover the forces that influence changes in chromosome numbers and the implications for genetic disorders such as Klinefelter syndrome. Patients may benefit from insights gained about the genetic basis of these conditions, which could lead to improved diagnosis and treatment options. The research will analyze genomic data across various species to understand these evolutionary processes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with chromosomal disorders such as Klinefelter syndrome or Turner syndrome.
Not a fit: Patients with non-genetic conditions or those without chromosomal abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic disorders linked to sex chromosomes, potentially leading to better diagnostic and therapeutic strategies.
How similar studies have performed: While the approach is innovative, previous research has shown that understanding genome evolution can lead to significant advancements in the field of genetics.
Where this research is happening
COLLEGE STATION, UNITED STATES
- TEXAS A&M UNIVERSITY — COLLEGE STATION, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BLACKMON, HEATH — TEXAS A&M UNIVERSITY
- Study coordinator: BLACKMON, HEATH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Chromosomal Disorders, Chromosome Abnormality Disorders, Chromosome Disorders, Congenital chromosomal disease