Understanding how sex and obesity affect blood pressure during low oxygen levels
Sex disparities in hypoxic sympatholysis and impact of obesity
This study looks at how men and women respond differently to low oxygen levels in the body and how being overweight might change that response, especially focusing on young women who are at a healthy weight, to help us better understand heart health for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11119217 on NIH RePORTER |
What this research studies
This research investigates how the body's response to low oxygen levels differs between sexes and how obesity influences this response. It focuses on the sympathetic nervous system, which regulates blood pressure and blood flow, particularly during hypoxic conditions. The study aims to identify the mechanisms behind these differences, especially in young women who are normal weight, and how obesity may alter these responses. By examining these factors, the research seeks to enhance our understanding of cardiovascular health in relation to sex and weight.
Who could benefit from this research
Good fit: Ideal candidates for this research include young, premenopausal women who are of normal weight, as well as individuals with obesity.
Not a fit: Patients who are not within the age range of 21+ years or those who do not have conditions related to hypoxia or obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for hypertension and cardiovascular diseases, particularly in women and obese individuals.
How similar studies have performed: Previous research has indicated significant sex differences in cardiovascular responses, suggesting that this study builds on established findings rather than exploring entirely novel territory.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Limberg, Jacqueline K — University of Missouri-Columbia
- Study coordinator: Limberg, Jacqueline K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.