Understanding how sex and gender affect disease differences
Networks Tools to Understand Sex- and Gender-Specific Drivers of Disease
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10885112
This study is looking at how men and women might experience diseases like COPD and cancer differently, by exploring the biological reasons behind these differences, with the goal of creating better, more personalized treatments for everyone.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10885112 on ClinicalTrials.gov |
What this research studies
This research investigates the differences in disease risk, progression, and treatment responses between males and females, particularly focusing on complex diseases like chronic obstructive pulmonary disease and various cancers. By analyzing DNA methylation and gene regulatory processes, the study aims to uncover the biological factors that contribute to these sex-based differences. The research will develop new tools to model these differences and assess how they evolve over a person's lifespan, potentially leading to more personalized treatment approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with chronic obstructive pulmonary disease or cancers, particularly those interested in how their sex may influence their disease experience.
Not a fit: Patients who do not have chronic obstructive pulmonary disease or cancers may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies tailored to the specific needs of male and female patients.
How similar studies have performed: Previous research has shown that understanding sex-based differences in disease can lead to significant advancements in treatment, indicating that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DEMEO, DAWN L — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: DEMEO, DAWN L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease