Understanding how severe burn injuries affect the immune system
Official title: Elucidating the Mechanisms of Immune Dysfunction After Severe Burn Injury
Funded at Research Inst Nationwide Children's Hosp · NIH-10911216 · Data updated 2026-11-12
This study is looking at how severe burn injuries affect the immune system in kids, with the hope of finding ways to help them recover better and avoid infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $390,000 |
| NIH project number | 5R35GM151165-02 |
| Project ID | NIH-10911216 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pediatric patients who have experienced severe burn injuries.
✕Less likely to help
Patients who have not suffered from severe burn injuries are unlikely to benefit from this research.
What this research studies
This research investigates the immune dysfunction that occurs after severe burn injuries, particularly in pediatric patients. By analyzing blood and tissue samples from children who have suffered burns, the study aims to identify the mechanisms that lead to immune system complications, such as increased risk of infections. The research will utilize both human samples and a juvenile mouse model to explore how burn injuries impact immune cell function and to develop potential biomarkers for identifying at-risk patients. Ultimately, the goal is to create therapies that can improve outcomes for children recovering from severe burns.
Why it matters
Potential benefit: If successful, this research could lead to better identification and treatment of infections in children who have suffered severe burns.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in burn injuries, but this specific approach is novel in its focus on pediatric populations.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Thakkar, Rajan — Research Inst Nationwide Children's Hosp
- Study coordinator: Thakkar, Rajan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.