Understanding how SETD4 affects the function of a key protein involved in DNA repair.
Regulation of Ku70 methylation and functions by SETD4
This study is looking at how a protein called SETD4 helps control another protein, Ku70, which is important for fixing DNA damage, and by understanding this process better, we hope to find new ways to improve cancer treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11003973 on NIH RePORTER |
What this research studies
This research investigates the role of SETD4 in regulating the methylation of Ku70, a protein essential for repairing DNA damage. By studying how SETD4 influences Ku70's movement and function, the research aims to uncover new mechanisms that could affect cell survival and apoptosis. The approach combines biochemistry, cell biology, and mouse genetics to explore these interactions in detail. Patients may benefit from insights gained about DNA repair processes that could lead to new cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that involve DNA damage and repair mechanisms.
Not a fit: Patients with non-cancerous conditions or those not affected by DNA repair deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing DNA repair mechanisms in cancer treatment.
How similar studies have performed: Other research has shown promising results in understanding protein regulation in DNA repair, suggesting potential for success in this area.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Shen, Zhiyuan — Rutgers Biomedical and Health Sciences
- Study coordinator: Shen, Zhiyuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.