Understanding how serum amyloid A contributes to heart disease
Mechanisms regulating the atherogenic activities of serum amyloid A
This study is looking at how a protein called serum amyloid A (SAA) affects heart health, especially in people with conditions like diabetes and obesity, to find new ways to predict and prevent heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10636872 on NIH RePORTER |
What this research studies
This research investigates the role of serum amyloid A (SAA) in the development of atherosclerosis, a condition that leads to cardiovascular disease. It focuses on how SAA levels rise during inflammation and remain elevated in chronic conditions like diabetes and obesity. By studying the interactions of SAA with lipoproteins and its effects on inflammation, the research aims to uncover mechanisms that could help predict and prevent cardiovascular events. Patients may benefit from insights that could lead to new treatments or preventive strategies for heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with chronic inflammatory conditions such as diabetes, obesity, or rheumatoid arthritis.
Not a fit: Patients without any cardiovascular risk factors or chronic inflammatory conditions may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for predicting and preventing cardiovascular disease in at-risk patients.
How similar studies have performed: Previous research has shown that understanding the role of inflammatory markers like SAA can lead to significant advancements in cardiovascular disease management.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Shridas, Preetha — University of Kentucky
- Study coordinator: Shridas, Preetha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.