Understanding how sertraline affects pregnant women with depression
Official title: Pharmacokinetic/Pharmacodynamic model in pregnant women with depression to guide sertraline dosing
Funded at University of Minnesota · NIH-10685934 · Data updated 2026-11-12
This study is looking at how the antidepressant sertraline affects pregnant women with depression and anxiety, aiming to find the best way to use it so that moms can feel better while keeping their babies safe and healthy.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | August 18, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $189,233 |
| NIH project number | 5R21HD105297-02 |
| Project ID | NIH-10685934 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant women who are experiencing depression or anxiety and are prescribed sertraline.
✕Less likely to help
Patients who are not pregnant or those who do not have depression or anxiety may not benefit from this research.
What this research studies
This research investigates how the antidepressant sertraline works in pregnant women suffering from depression and anxiety. It aims to understand the changes in drug levels during pregnancy and how these changes impact both the mother's mental health and the health of the baby. By analyzing data from a large database of women with neuropsychiatric conditions, the study will use advanced modeling techniques to determine the best dosing strategies for sertraline during pregnancy. This approach seeks to ensure that mothers receive effective treatment while minimizing risks to their newborns.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer antidepressant dosing for pregnant women, improving maternal and neonatal health outcomes.
How similar studies have gone: Previous research has shown that pharmacokinetic modeling can effectively optimize medication dosing in various populations, suggesting potential success for this approach in pregnant women.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Illamola, Silvia Martinez — University of Minnesota
- Study coordinator: Illamola, Silvia Martinez
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.