Understanding how Serratia marcescens bacteria resist polymyxin antibiotics
Delineating genetic determinants of polymyxin resistance in Serratia marcescens
['FUNDING_R21'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10462801
This study is looking at how certain bacteria can resist important antibiotics, which can help us find better ways to treat infections caused by them.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10462801 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors that allow Serratia marcescens, a type of bacteria, to resist polymyxin antibiotics, which are crucial for treating certain infections. The team is analyzing different strains of these bacteria to identify specific genetic changes that contribute to their resistance. By using advanced techniques like whole genome sequencing, they aim to uncover the molecular mechanisms behind this resistance, which could lead to better treatment options for patients with infections caused by these bacteria.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with infections caused by Serratia marcescens, particularly those who have developed resistance to carbapenem antibiotics.
Not a fit: Patients with infections caused by other types of bacteria that do not involve Serratia marcescens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients suffering from infections caused by carbapenem-resistant Serratia marcescens.
How similar studies have performed: Previous research has shown success in understanding antibiotic resistance mechanisms in other bacterial species, suggesting that this approach may yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: UHLEMANN, ANNE-CATRIN — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: UHLEMANN, ANNE-CATRIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.